(89)Zr-pembrolizumab biodistribution is influenced by PD-1-mediated uptake in lymphoid organs

BACKGROUND: To better predict response to immune checkpoint therapy and toxicity in healthy tissues, insight in the in vivo behavior of immune checkpoint targeting monoclonal antibodies is essential. Therefore, we aimed to study in vivo pharmacokinetics and whole-body distribution of zirconium-89 ((...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: van der Veen, Elly L, Giesen, Danique, Pot-de Jong, Linda, Jorritsma-Smit, Annelies, De Vries, Elisabeth G E, Lub-de Hooge, Marjolijn N
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Clinical/Translational Cancer Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537332/
https://ncbi.nlm.nih.gov/pubmed/33020241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000938
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