(89)Zr-pembrolizumab biodistribution is influenced by PD-1-mediated uptake in lymphoid organs

BACKGROUND: To better predict response to immune checkpoint therapy and toxicity in healthy tissues, insight in the in vivo behavior of immune checkpoint targeting monoclonal antibodies is essential. Therefore, we aimed to study in vivo pharmacokinetics and whole-body distribution of zirconium-89 ((...

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Foilsithe in:J Immunother Cancer
Main Authors: van der Veen, Elly L, Giesen, Danique, Pot-de Jong, Linda, Jorritsma-Smit, Annelies, De Vries, Elisabeth G E, Lub-de Hooge, Marjolijn N
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMJ Publishing Group 2020
Ábhair:
Clinical/Translational Cancer Immunotherapy
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537332/
https://ncbi.nlm.nih.gov/pubmed/33020241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000938
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