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Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection

SHP1 is a tyrosine phosphatase critical to proximal regulation of TCR signaling. Here, analysis of CD4-Cre SHP1(fl/fl) conditional knockout thymocytes using CD53, TCRβ, CD69, CD4 and CD8α expression demonstrates the importance of SHP1 in the survival of post selection (CD53(+)), single-positive thym...

詳細記述

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書誌詳細
出版年:Eur J Immunol
主要な著者: Martinez, Ryan J, Morris, Anna B, Neeld, Dennis K, Evavold, Brian D
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5208044/
https://ncbi.nlm.nih.gov/pubmed/27354309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201646475
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