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Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection
SHP1 is a tyrosine phosphatase critical to proximal regulation of TCR signaling. Here, analysis of CD4-Cre SHP1(fl/fl) conditional knockout thymocytes using CD53, TCRβ, CD69, CD4 and CD8α expression demonstrates the importance of SHP1 in the survival of post selection (CD53(+)), single-positive thym...
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| Publicado no: | Eur J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5208044/ https://ncbi.nlm.nih.gov/pubmed/27354309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201646475 |
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