PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma

The unfolded protein response (UPR) regulates cell fate following exposure of cells to endoplasmic reticulum stresses. PERK, a UPR protein kinase, regulates protein synthesis and while linked with cell survival, exhibits activities associated with both tumor progression and tumor suppression. For ex...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Pytel, Dariusz, Gao, Yan, Mackiewicz, Katarzyna, Katlinskaya, Yuliya V., Staschke, Kirk A., Paredes, Maria C. G., Yoshida, Akihiro, Qie, Shuo, Zhang, Gao, Chajewski, Olga S., Wu, Lawrence, Majsterek, Ireneusz, Herlyn, Meenhard, Fuchs, Serge Y., Diehl, J. Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207760/
https://ncbi.nlm.nih.gov/pubmed/27977682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006518
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados