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Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer’s Disease

Recent evidence suggests that the development of Alzheimer’s disease (AD) and related cognitive loss is due to mutations in the Amyloid Precursor Protein (APP) gene on chromosome 21 and increased activation of eukaryotic translation initiation factor-2α (eIF2α) phosphorylation. The high level of mis...

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Detalhes bibliográficos
Publicado no:Curr Med Chem
Main Authors: Rozpędek, Wioletta, Markiewicz, Łukasz, Diehl, J. Alan, Pytel, Dariusz, Majsterek, Ireneusz
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010237/
https://ncbi.nlm.nih.gov/pubmed/26282939
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