Substrates and Inhibitors of SAMHD1

SAMHD1 hydrolyzes 2'-deoxynucleoside-5'-triphosphates (dNTPs) into 2'-deoxynucleosides and inorganic triphosphate products. In this paper, we evaluated the impact of 2' sugar moiety substitution for different nucleotides on being substrates for SAMHD1 and mechanisms of actions fo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hollenbaugh, Joseph A., Shelton, Jadd, Tao, Sijia, Amiralaei, Sheida, Liu, Peng, Lu, Xiao, Goetze, Russell W., Zhou, Longhu, Nettles, James H., Schinazi, Raymond F., Kim, Baek
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207538/
https://ncbi.nlm.nih.gov/pubmed/28046007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169052
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