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Nickel-catalyzed enantioselective arylation of pyridine

We report an enantioselective Ni-catalyzed cross coupling of arylzinc reagents with pyridinium ions formed in situ from pyridine and a chloroformate. This reaction provides enantioenriched 2-aryl-1,2-dihydropyridine products that can be elaborated to numerous piperidine derivatives with little or no...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Lutz, J. Patrick, Chau, Stephen T., Doyle, Abigail G.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207490/
https://ncbi.nlm.nih.gov/pubmed/28058106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00702c
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