Interferon-γ Promotes Antibody-mediated Fratricide of Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) is characterized by the proliferation of immature myeloid lineage blasts. Due to its heterogeneity and to the high rate of acquired drug resistance and relapse, new treatment strategies are needed. Here, we demonstrate that IFNγ promotes AML blasts to act as effector cel...

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Publicado en:J Biol Chem
Autores principales: Fatehchand, Kavin, McMichael, Elizabeth L., Reader, Brenda F., Fang, Huiqing, Santhanam, Ramasamy, Gautam, Shalini, Elavazhagan, Saranya, Mehta, Payal, Buteyn, Nathaniel J., Merchand-Reyes, Giovanna, Vasu, Sumithira, Mo, Xiaokui, Benson, Don M., Blachly, James S., Carson, William E., Byrd, John C., Butchar, Jonathan P., Tridandapani, Susheela
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207262/
https://ncbi.nlm.nih.gov/pubmed/27780867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753145
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