Interferon-γ Promotes Antibody-mediated Fratricide of Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) is characterized by the proliferation of immature myeloid lineage blasts. Due to its heterogeneity and to the high rate of acquired drug resistance and relapse, new treatment strategies are needed. Here, we demonstrate that IFNγ promotes AML blasts to act as effector cel...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fatehchand, Kavin, McMichael, Elizabeth L., Reader, Brenda F., Fang, Huiqing, Santhanam, Ramasamy, Gautam, Shalini, Elavazhagan, Saranya, Mehta, Payal, Buteyn, Nathaniel J., Merchand-Reyes, Giovanna, Vasu, Sumithira, Mo, Xiaokui, Benson, Don M., Blachly, James S., Carson, William E., Byrd, John C., Butchar, Jonathan P., Tridandapani, Susheela
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207262/
https://ncbi.nlm.nih.gov/pubmed/27780867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753145
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