Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction

PGC-1-related coactivator (PRC) has a dual function in growth-regulated mitochondrial biogenesis and as a sensor of metabolic stress. PRC induction by mitochondrial inhibitors, intracellular ROS, or topoisomerase I inhibition orchestrates an inflammatory program associated with the adaptation to cel...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Gleyzer, Natalie, Scarpulla, Richard C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207252/
https://ncbi.nlm.nih.gov/pubmed/27789709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.719682
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