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Short Hairpin RNA-mediated Silencing of PRC (PGC-1-related Coactivator) Results in a Severe Respiratory Chain Deficiency Associated with the Proliferation of Aberrant Mitochondria

PRC, a member of the PGC-1 coactivator family, is responsive to serum growth factors and up-regulated in proliferating cells. Here, we investigated its in vivo role by stably silencing PRC expression with two different short hairpin RNAs (shRNA1 and shRNA4) that were lentivirally introduced into U2O...

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書誌詳細
主要な著者: Vercauteren, Kristel, Gleyzer, Natalie, Scarpulla, Richard C.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629116/
https://ncbi.nlm.nih.gov/pubmed/19036724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806434200
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