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PGC-1-related Coactivator (PRC), a Sensor of Metabolic Stress, Orchestrates a Redox-sensitive Program of Inflammatory Gene Expression
PGC-1-related coactivator (PRC) is a growth-regulated transcriptional cofactor that activates many nuclear genes specifying mitochondrial respiratory function. Stable PRC silencing in U2OS cells results in a complex phenotype typical of mitochondrial dysfunction including abundant abnormal mitochond...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220587/ https://ncbi.nlm.nih.gov/pubmed/21937425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.291575 |
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