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PGC-1-related Coactivator (PRC), a Sensor of Metabolic Stress, Orchestrates a Redox-sensitive Program of Inflammatory Gene Expression

PGC-1-related coactivator (PRC) is a growth-regulated transcriptional cofactor that activates many nuclear genes specifying mitochondrial respiratory function. Stable PRC silencing in U2OS cells results in a complex phenotype typical of mitochondrial dysfunction including abundant abnormal mitochond...

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Bibliografiska uppgifter
Huvudupphovsmän: Gleyzer, Natalie, Scarpulla, Richard C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220587/
https://ncbi.nlm.nih.gov/pubmed/21937425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.291575
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