Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands

The pre-T cell receptor (pre-TCR) is a pTα-β heterodimer functioning in early αβ T cell development. Although once thought to be ligand-autonomous, recent studies show that pre-TCRs participate in thymic repertoire formation through recognition of peptides bound to major histocompatibility molecules...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Das, Dibyendu Kumar, Mallis, Robert J., Duke-Cohan, Jonathan S., Hussey, Rebecca E., Tetteh, Paul W., Hilton, Mark, Wagner, Gerhard, Lang, Matthew J., Reinherz, Ellis L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Papers of the Week
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207233/
https://ncbi.nlm.nih.gov/pubmed/27707880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752865
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