The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity, and Cardiac Function in Zebrafish

Calmodulin (CaM) is a Ca(2+) binding protein modulating multiple targets, several of which are associated with cardiac pathophysiology. Recently, CaM mutations were linked to heart arrhythmia. CaM is crucial for cell growth and viability, yet the effect of the arrhythmogenic CaM mutations on cell vi...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Berchtold, Martin W., Zacharias, Triantafyllos, Kulej, Katarzyna, Wang, Kevin, Torggler, Raffaela, Jespersen, Thomas, Chen, Jau-Nian, Larsen, Martin R., la Cour, Jonas M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207174/
https://ncbi.nlm.nih.gov/pubmed/27815504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.758680
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