The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity, and Cardiac Function in Zebrafish

Calmodulin (CaM) is a Ca(2+) binding protein modulating multiple targets, several of which are associated with cardiac pathophysiology. Recently, CaM mutations were linked to heart arrhythmia. CaM is crucial for cell growth and viability, yet the effect of the arrhythmogenic CaM mutations on cell vi...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Berchtold, Martin W., Zacharias, Triantafyllos, Kulej, Katarzyna, Wang, Kevin, Torggler, Raffaela, Jespersen, Thomas, Chen, Jau-Nian, Larsen, Martin R., la Cour, Jonas M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207174/
https://ncbi.nlm.nih.gov/pubmed/27815504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.758680
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