The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity, and Cardiac Function in Zebrafish

Calmodulin (CaM) is a Ca(2+) binding protein modulating multiple targets, several of which are associated with cardiac pathophysiology. Recently, CaM mutations were linked to heart arrhythmia. CaM is crucial for cell growth and viability, yet the effect of the arrhythmogenic CaM mutations on cell vi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Berchtold, Martin W., Zacharias, Triantafyllos, Kulej, Katarzyna, Wang, Kevin, Torggler, Raffaela, Jespersen, Thomas, Chen, Jau-Nian, Larsen, Martin R., la Cour, Jonas M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207174/
https://ncbi.nlm.nih.gov/pubmed/27815504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.758680
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