Oxidative Unfolding of the Rubredoxin Domain and the Natively Disordered N-terminal Region Regulate the Catalytic Activity of Mycobacterium tuberculosis Protein Kinase G

Mycobacterium tuberculosis escapes killing in human macrophages by secreting protein kinase G (PknG). PknG intercepts host signaling to prevent fusion of the phagosome engulfing the mycobacteria with the lysosome and, thus, their degradation. The N-terminal NORS (no regulatory secondary structure) r...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wittwer, Matthias, Luo, Qi, Kaila, Ville R. I., Dames, Sonja A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207137/
https://ncbi.nlm.nih.gov/pubmed/27810897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.747089
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