Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer

Chimeric antigen receptor T (CAR-T) cells have demonstrated promising results against hematological malignancies but have encountered significant challenges in translation to solid tumors. To overcome these hurdles, we have developed a switchable CAR-T cell platform in which the activity of the engi...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Cao, Yu, Rodgers, David T., Du, Juanjuan, Ahmad, Insha, Hampton, Eric N., Ma, Jennifer S. Y., Mazagova, Magdalena, Choi, Sei-hyun, Yun, Hwa Young, Xiao, Han, Yang, Pengyu, Luo, Xiaozhou, Lim, Reyna K. V., Pugh, Holly M., Wang, Feng, Kazane, Stephanie A., Wright, Timothy M., Kim, Chan Hyuk, Schultz, Peter G., Young, Travis S.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207029/
https://ncbi.nlm.nih.gov/pubmed/27145250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201601902
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