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Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus

Three series (6, 13, and 14) of new diarylaniline (DAAN) analogues were designed, synthesized, and evaluated for anti-HIV potency, especially against the E138K viral strain with a major mutation conferring resistance to the new-generation non-nucleoside reverse transcriptase inhibitor drug rilpiviri...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Liu, Na, Wei, Lei, Huang, Li, Yu, Fei, Zheng, Weifan, Qin, Bingjie, Zhu, Dong-Qin, Morris-Natschke, Susan L., Jiang, Shibo, Chen, Chin-Ho, Lee, Kuo-Hsiung, Xie, Lan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206802/
https://ncbi.nlm.nih.gov/pubmed/27070547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01827
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