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Physicochemical Property-Driven Optimization of Diarylaniline Compounds as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
Using physicochemical property-driven optimization, twelve new diarylaniline compounds (DAANs) (7a–h, 11a–b and 12a–b) were designed and synthesized. Among them, compounds 12a–b not only showed high potency (EC(50) 0.96–4.92 nM) against both wild-type and drug-resistant viral strains with the lowest...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4137035/ https://ncbi.nlm.nih.gov/pubmed/25042339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.07.011 |
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