Physicochemical Property-Driven Optimization of Diarylaniline Compounds as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Using physicochemical property-driven optimization, twelve new diarylaniline compounds (DAANs) (7a–h, 11a–b and 12a–b) were designed and synthesized. Among them, compounds 12a–b not only showed high potency (EC(50) 0.96–4.92 nM) against both wild-type and drug-resistant viral strains with the lowest...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Liu, Na, Qin, Bingjie, Sun, Lian-Qi, Yu, Fei, Lu, Lu, Jiang, Shibo, Lee, Kuo-Hsiung, Xie, Lan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137035/
https://ncbi.nlm.nih.gov/pubmed/25042339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.07.011
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky