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Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE
Noncoding transcripts originating upstream of the immunoglobulin constant region (I transcripts) are required to direct activation-induced deaminase to initiate class switching in B cells. Differential regulation of Iε and Iγ1 transcription in response to interleukin 4 (IL-4), hence class switching...
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| Publicado no: | J Exp Med |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5206502/ https://ncbi.nlm.nih.gov/pubmed/27994069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161056 |
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