CD4(+) T cell effector commitment coupled to self-renewal by asymmetric cell divisions

Upon infection, an activated CD4(+) T cell produces terminally differentiated effector cells and renews itself for continued defense. In this study, we show that differentiation and self-renewal arise as opposing outcomes of sibling CD4(+) T cells. After influenza challenge, antigen-specific cells u...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Nish, Simone A., Zens, Kyra D., Kratchmarov, Radomir, Lin, Wen-Hsuan W., Adams, William C., Chen, Yen-Hua, Yen, Bonnie, Rothman, Nyanza J., Bhandoola, Avinash, Xue, Hai-Hui, Farber, Donna L., Reiner, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206501/
https://ncbi.nlm.nih.gov/pubmed/27923906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161046
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