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All-atom/coarse-grained hybrid predictions of distribution coefficients in SAMPL5

We present blind predictions submitted to the SAMPL5 challenge on calculating distribution coefficients. The predictions were based on estimating the solvation free energies in water and cyclohexane of the 53 compounds in the challenge. These free energies were computed using alchemical free energy...

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Detalhes bibliográficos
Publicado no:J Comput Aided Mol Des
Main Authors: Genheden, Samuel, Essex, Jonathan W.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206257/
https://ncbi.nlm.nih.gov/pubmed/27460060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-016-9926-z
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