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All-atom/coarse-grained hybrid predictions of distribution coefficients in SAMPL5

We present blind predictions submitted to the SAMPL5 challenge on calculating distribution coefficients. The predictions were based on estimating the solvation free energies in water and cyclohexane of the 53 compounds in the challenge. These free energies were computed using alchemical free energy...

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Foilsithe in:J Comput Aided Mol Des
Main Authors: Genheden, Samuel, Essex, Jonathan W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer International Publishing 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206257/
https://ncbi.nlm.nih.gov/pubmed/27460060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-016-9926-z
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