The number of positively charged amino acids in the basic domain of Tat is critical for trans-activation and complex formation with TAR RNA.

The basic domain of Tat is required for trans-activation of viral gene expression. We have performed scanning peptide studies to demonstrate that only this domain is capable of binding to the TAR RNA stem-loop. Strikingly, the basic domain of the other human immunodeficiency virus trans-acting facto...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Delling, U, Roy, S, Sumner-Smith, M, Barnett, R, Reid, L, Rosen, C A, Sonenberg, N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52057/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2068104/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.14.6234
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