The number of positively charged amino acids in the basic domain of Tat is critical for trans-activation and complex formation with TAR RNA.

Ítems similars

• Conserved nucleotides in the TAR RNA stem of human immunodeficiency virus type 1 are critical for Tat binding and trans activation: model for TAR RNA tertiary structure.
  per: Delling, U, et al.
  Publicat: (1992)
• Critical chemical features in trans-acting-responsive RNA are required for interaction with human immunodeficiency virus type 1 Tat protein.
  per: Sumner-Smith, M, et al.
  Publicat: (1991)
• Rotational symmetry in ribonucleotide strand requirements for binding of HIV-1 Tat protein to TAR RNA.
  per: Barnett, R W, et al.
  Publicat: (1993)
• The basic RNA-binding domain of HIV-2 Tat contributes to preferential trans-activation of a TAR2-containing LTR.
  per: Chang, Y N, et al.
  Publicat: (1992)
• Juxtaposition between activation and basic domains of human immunodeficiency virus type 1 Tat is required for optimal interactions between Tat and TAR.
  per: Luo, Y, et al.
  Publicat: (1993)