Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α

Glucocorticoids (GCs) regulate energy supply in response to stress by increasing hepatic gluconeogenesis during fasting. Long-term GC treatment induces hepatic steatosis and weight gain. GC signaling is coordinated via the GC receptor (GR) GRα, as the GRβ isoform lacks a ligand-binding domain. The r...

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Publicado en:J Biol Chem
Autores principales: Marino, Joseph S., Stechschulte, Lance A., Stec, David E., Nestor-Kalinoski, Andrea, Coleman, Sydni, Hinds, Terry D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203696/
https://ncbi.nlm.nih.gov/pubmed/27784782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752311
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