Mice with hyperbilirubinemia due to Gilbert’s syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα

Gilbert’s syndrome in humans is derived from a polymorphism (TA repeat) in the hepatic UGT1A1 gene that results in decreased conjugation and increased levels of unconjugated bilirubin. Recently, we have shown that bilirubin binds directly to the fat-burning nuclear peroxisome proliferator-activated...

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Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Hinds, Terry D., Hosick, Peter A., Chen, Shujuan, Tukey, Robert H., Hankins, Michael W., Nestor-Kalinoski, Andrea, Stec, David E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406988/
https://ncbi.nlm.nih.gov/pubmed/28096081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00396.2016
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