Glucocorticoid Receptor β Stimulates Akt1 Growth Pathway by Attenuation of PTEN

Glucocorticoids (GCs) are known inhibitors of proliferation and are commonly prescribed to cancer patients to inhibit tumor growth and induce apoptosis via the glucocorticoid receptor (GR). Because of alternative splicing, the GR exists as two isoforms, GRα and GRβ. The growth inhibitory actions of...

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Bibliographische Detailangaben
Hauptverfasser: Stechschulte, Lance A., Wuescher, Leah, Marino, Joseph S., Hill, Jennifer W., Eng, Charis, Hinds, Terry D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067219/
https://ncbi.nlm.nih.gov/pubmed/24817119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544072
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