Nuclear PTEN-Mediated Growth Suppression Is Independent of Akt Down-Regulation

The tumor suppressor gene PTEN is a phosphoinositide phosphatase that is inactivated by deletion and/or mutation in diverse human tumors. Wild-type PTEN is expressed both in the cytoplasm and nucleus in normal cells, with a preferential nuclear localization in differentiated or resting cells. To elu...

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Detalhes bibliográficos
Main Authors: Liu, Juinn-Lin, Sheng, Xiaoyang, Hortobagyi, Zsuzsanna K., Mao, Zhenyu, Gallick, Gary E., Yung, W. K. Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168816/
https://ncbi.nlm.nih.gov/pubmed/15988030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.14.6211-6224.2005
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