Biallelic mutations in IRF8 impair human NK cell maturation and function

Human NK cell deficiencies are rare yet result in severe and often fatal disease, particularly as a result of viral susceptibility. NK cells develop from hematopoietic stem cells, and few monogenic errors that specifically interrupt NK cell development have been reported. Here we have described bial...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Mace, Emily M., Bigley, Venetia, Gunesch, Justin T., Chinn, Ivan K., Angelo, Laura S., Care, Matthew A., Maisuria, Sheetal, Keller, Michael D., Togi, Sumihito, Watkin, Levi B., LaRosa, David F., Jhangiani, Shalini N., Muzny, Donna M., Stray-Pedersen, Asbjørg, Coban Akdemir, Zeynep, Smith, Jansen B., Hernández-Sanabria, Mayra, Le, Duy T., Hogg, Graham D., Cao, Tram N., Freud, Aharon G., Szymanski, Eva P., Savic, Sinisa, Collin, Matthew, Cant, Andrew J., Gibbs, Richard A., Holland, Steven M., Caligiuri, Michael A., Ozato, Keiko, Paust, Silke, Doody, Gina M., Lupski, James R., Orange, Jordan S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199714/
https://ncbi.nlm.nih.gov/pubmed/27893462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86276
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