Biallelic mutations in IRF8 impair human NK cell maturation and function

Human NK cell deficiencies are rare yet result in severe and often fatal disease, particularly as a result of viral susceptibility. NK cells develop from hematopoietic stem cells, and few monogenic errors that specifically interrupt NK cell development have been reported. Here we have described bial...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Clin Invest
المؤلفون الرئيسيون: Mace, Emily M., Bigley, Venetia, Gunesch, Justin T., Chinn, Ivan K., Angelo, Laura S., Care, Matthew A., Maisuria, Sheetal, Keller, Michael D., Togi, Sumihito, Watkin, Levi B., LaRosa, David F., Jhangiani, Shalini N., Muzny, Donna M., Stray-Pedersen, Asbjørg, Coban Akdemir, Zeynep, Smith, Jansen B., Hernández-Sanabria, Mayra, Le, Duy T., Hogg, Graham D., Cao, Tram N., Freud, Aharon G., Szymanski, Eva P., Savic, Sinisa, Collin, Matthew, Cant, Andrew J., Gibbs, Richard A., Holland, Steven M., Caligiuri, Michael A., Ozato, Keiko, Paust, Silke, Doody, Gina M., Lupski, James R., Orange, Jordan S.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2016
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199714/
https://ncbi.nlm.nih.gov/pubmed/27893462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86276
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