Biallelic mutations in IRF8 impair human NK cell maturation and function

Human NK cell deficiencies are rare yet result in severe and often fatal disease, particularly as a result of viral susceptibility. NK cells develop from hematopoietic stem cells, and few monogenic errors that specifically interrupt NK cell development have been reported. Here we have described bial...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Mace, Emily M., Bigley, Venetia, Gunesch, Justin T., Chinn, Ivan K., Angelo, Laura S., Care, Matthew A., Maisuria, Sheetal, Keller, Michael D., Togi, Sumihito, Watkin, Levi B., LaRosa, David F., Jhangiani, Shalini N., Muzny, Donna M., Stray-Pedersen, Asbjørg, Coban Akdemir, Zeynep, Smith, Jansen B., Hernández-Sanabria, Mayra, Le, Duy T., Hogg, Graham D., Cao, Tram N., Freud, Aharon G., Szymanski, Eva P., Savic, Sinisa, Collin, Matthew, Cant, Andrew J., Gibbs, Richard A., Holland, Steven M., Caligiuri, Michael A., Ozato, Keiko, Paust, Silke, Doody, Gina M., Lupski, James R., Orange, Jordan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199714/
https://ncbi.nlm.nih.gov/pubmed/27893462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86276
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