Pancreatic β cell identity requires continual repression of non–β cell programs

Loss of β cell identity, the presence of polyhormonal cells, and reprogramming are emerging as important features of β cell dysfunction in patients with type 1 and type 2 diabetes. In this study, we have demonstrated that the transcription factor NKX2.2 is essential for the active maintenance of adu...

Full description

Saved in:
Bibliographic Details
Published in:J Clin Invest
Main Authors: Gutiérrez, Giselle Domínguez, Bender, Aaron S., Cirulli, Vincenzo, Mastracci, Teresa L., Kelly, Stephen M., Tsirigos, Aristotelis, Kaestner, Klaus H., Sussel, Lori
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199704/
https://ncbi.nlm.nih.gov/pubmed/27941248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88017
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items