Pancreatic β cell identity requires continual repression of non–β cell programs

Loss of β cell identity, the presence of polyhormonal cells, and reprogramming are emerging as important features of β cell dysfunction in patients with type 1 and type 2 diabetes. In this study, we have demonstrated that the transcription factor NKX2.2 is essential for the active maintenance of adu...

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發表在:J Clin Invest
Main Authors: Gutiérrez, Giselle Domínguez, Bender, Aaron S., Cirulli, Vincenzo, Mastracci, Teresa L., Kelly, Stephen M., Tsirigos, Aristotelis, Kaestner, Klaus H., Sussel, Lori
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2016
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199704/
https://ncbi.nlm.nih.gov/pubmed/27941248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88017
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