Epigenome-wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-lethal Progression in Men with Clinically Localized Prostate Cancer

PURPOSE: Aside from Gleason sum few factors accurately identify the subset of prostate cancer (PCa) patients at high risk for metastatic progression. We hypothesized that epigenetic alterations could distinguish prostate tumors with life-threatening potential. EXPERIMENTAL DESIGN: Epigenome-wide DNA...

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Pubblicato in:Clin Cancer Res
Autori principali: Zhao, Shanshan, Geybels, Milan S., Leonardson, Amy, Rubicz, Rohina, Kolb, Suzanne, Yan, Qingxiang, Klotzle, Brandy, Bibikova, Marina, Hurtado-Coll, Antonio, Troyer, Dean, Lance, Raymond, Lin, Daniel W., Wright, Jonathan L., Ostrander, Elaine A., Fan, Jian-Bing, Feng, Ziding, Stanford, Janet L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199634/
https://ncbi.nlm.nih.gov/pubmed/27358489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0549
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