Epigenome-wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-lethal Progression in Men with Clinically Localized Prostate Cancer

PURPOSE: Aside from Gleason sum few factors accurately identify the subset of prostate cancer (PCa) patients at high risk for metastatic progression. We hypothesized that epigenetic alterations could distinguish prostate tumors with life-threatening potential. EXPERIMENTAL DESIGN: Epigenome-wide DNA...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Zhao, Shanshan, Geybels, Milan S., Leonardson, Amy, Rubicz, Rohina, Kolb, Suzanne, Yan, Qingxiang, Klotzle, Brandy, Bibikova, Marina, Hurtado-Coll, Antonio, Troyer, Dean, Lance, Raymond, Lin, Daniel W., Wright, Jonathan L., Ostrander, Elaine A., Fan, Jian-Bing, Feng, Ziding, Stanford, Janet L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199634/
https://ncbi.nlm.nih.gov/pubmed/27358489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0549
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