Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors

BACKGROUND: About half of all prostate cancers harbor the TMPRSS2:ERG (T2E) gene fusion. While T2E-positive and T2E-negative tumors represent specific molecular subtypes of prostate cancer (PCa), previous studies have not yet comprehensively investigated how these tumor subtypes differ at the epigen...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Geybels, Milan S., Alumkal, Joshi J., Luedeke, Manuel, Rinckleb, Antje, Zhao, Shanshan, Shui, Irene M., Bibikova, Marina, Klotzle, Brandy, van den Brandt, Piet A., Ostrander, Elaine A., Fan, Jian-Bing, Feng, Ziding, Maier, Christiane, Stanford, Janet L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676897/
https://ncbi.nlm.nih.gov/pubmed/26692910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0161-6
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