Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling

G protein–coupled receptors (GPCRs), the largest family of signaling receptors, are critically regulated by endosomal trafficking, suggesting that endosomes might provide new strategies for manipulating GPCR signaling. Here we test this hypothesis by focusing on class III phosphatidylinositol 3-kina...

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Publicat a:Mol Pharmacol
Autors principals: Uchida, Yasunori, Rutaganira, Florentine U., Jullié, Damien, Shokat, Kevan M., von Zastrow, Mark
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198513/
https://ncbi.nlm.nih.gov/pubmed/27821547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.106252
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