Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes

Klotho is a type-1 membrane protein predominantly produced in the kidney, the extracellular domain of which is secreted into the systemic circulation. Membranous and secreted Klotho protect organs, including the kidney, but whether and how Klotho directly protects the glomerular filter is unknown. H...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Kim, Ji-Hee, Xie, Jian, Hwang, Kyu-Hee, Wu, Yueh-Lin, Oliver, Noelynn, Eom, Minseob, Park, Kyu-Sang, Barrezueta, Nestor, Kong, In-Deok, Fracasso, R. Paul, Huang, Chou-Long, Cha, Seung-Kuy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198269/
https://ncbi.nlm.nih.gov/pubmed/27151926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015080888
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