Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes

Klotho is a type-1 membrane protein predominantly produced in the kidney, the extracellular domain of which is secreted into the systemic circulation. Membranous and secreted Klotho protect organs, including the kidney, but whether and how Klotho directly protects the glomerular filter is unknown. H...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Am Soc Nephrol
Main Authors: Kim, Ji-Hee, Xie, Jian, Hwang, Kyu-Hee, Wu, Yueh-Lin, Oliver, Noelynn, Eom, Minseob, Park, Kyu-Sang, Barrezueta, Nestor, Kong, In-Deok, Fracasso, R. Paul, Huang, Chou-Long, Cha, Seung-Kuy
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2017
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198269/
https://ncbi.nlm.nih.gov/pubmed/27151926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015080888
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