T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN

Th1 cells are central pathogenic mediators of crescentic GN (cGN). Mechanisms responsible for Th1 cell downregulation, however, remain widely unknown. Recently, it was proposed that activation of the Th1–characteristic transcription factor T-bet optimizes Foxp3(+) regulatory T (Treg) cells to counte...

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Bibliografiset tiedot
Julkaisussa:J Am Soc Nephrol
Päätekijät: Nosko, Anna, Kluger, Malte A., Diefenhardt, Paul, Melderis, Simon, Wegscheid, Claudia, Tiegs, Gisa, Stahl, Rolf A.K., Panzer, Ulf, Steinmetz, Oliver M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Nephrology 2017
Aiheet:
Basic Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198267/
https://ncbi.nlm.nih.gov/pubmed/27297951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070820
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