T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN

Th1 cells are central pathogenic mediators of crescentic GN (cGN). Mechanisms responsible for Th1 cell downregulation, however, remain widely unknown. Recently, it was proposed that activation of the Th1–characteristic transcription factor T-bet optimizes Foxp3(+) regulatory T (Treg) cells to counte...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Nosko, Anna, Kluger, Malte A., Diefenhardt, Paul, Melderis, Simon, Wegscheid, Claudia, Tiegs, Gisa, Stahl, Rolf A.K., Panzer, Ulf, Steinmetz, Oliver M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2017
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198267/
https://ncbi.nlm.nih.gov/pubmed/27297951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070820
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