IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN

Background Th17 cells are central pathogenic mediators of autoimmune disease, including many forms of GN. IL-10 receptor signaling (IL-10R) in regulatory T cells (Tregs) has been implicated in the downregulation of Th17 cells, but the underlying molecular mechanisms and functional relevance of this...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Diefenhardt, Paul, Nosko, Anna, Kluger, Malte A., Richter, Johannes V., Wegscheid, Claudia, Kobayashi, Yasushi, Tiegs, Gisa, Huber, Samuel, Flavell, Richard A., Stahl, Rolf A.K., Steinmetz, Oliver M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2018
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050938/
https://ncbi.nlm.nih.gov/pubmed/29866800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017091044
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