Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN

IL-6 can mediate proinflammatory effects, and IL-6 receptor (IL-6R) blockade as a treatment for inflammatory diseases has entered clinical practice. However, opposing effects of IL-6 have been observed in models of GN. Although IL-6 is proinflammatory in murine lupus nephritis, protective effects ha...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Luig, Michael, Kluger, Malte A., Goerke, Boeren, Meyer, Matthias, Nosko, Anna, Yan, Isabell, Scheller, Jürgen, Mittrücker, Hans-Willi, Rose-John, Stefan, Stahl, Rolf A.K., Panzer, Ulf, Steinmetz, Oliver M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2015
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483592/
https://ncbi.nlm.nih.gov/pubmed/25655068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014060620
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