T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN

Th1 cells are central pathogenic mediators of crescentic GN (cGN). Mechanisms responsible for Th1 cell downregulation, however, remain widely unknown. Recently, it was proposed that activation of the Th1–characteristic transcription factor T-bet optimizes Foxp3(+) regulatory T (Treg) cells to counte...

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Podrobná bibliografie
Vydáno v:J Am Soc Nephrol
Hlavní autoři: Nosko, Anna, Kluger, Malte A., Diefenhardt, Paul, Melderis, Simon, Wegscheid, Claudia, Tiegs, Gisa, Stahl, Rolf A.K., Panzer, Ulf, Steinmetz, Oliver M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2017
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198267/
https://ncbi.nlm.nih.gov/pubmed/27297951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070820
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