Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors

Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different antiangiogenic receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib, vatalanib) with their intratumoral distribution data...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: Torok, Szilvia, Rezeli, Melinda, Kelemen, Olga, Vegvari, Akos, Watanabe, Kenichi, Sugihara, Yutaka, Tisza, Anna, Marton, Timea, Kovacs, Ildiko, Tovari, Jozsef, Laszlo, Viktoria, Helbich, Thomas H., Hegedus, Balazs, Klikovits, Thomas, Hoda, Mir Alireza, Klepetko, Walter, Paku, Sandor, Marko-Varga, Gyorgy, Dome, Balazs
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5197073/
https://ncbi.nlm.nih.gov/pubmed/28042343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.16767
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