Localization of sunitinib, its metabolites and its target receptors in tumour-bearing mice: a MALDI-MS imaging study

BACKGROUND AND PURPOSE: The clinical effects of anti-angiogenic agents remain controversial. Therefore, elucidating the pharmacological properties of these compounds is a pivotal issue. EXPERIMENTAL APPROACH: The effects of treatment with sunitinib on tumour and normal tissues of mice bearing C-26 a...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Torok, S, Vegvari, A, Rezeli, M, Fehniger, T E, Tovari, J, Paku, S, Laszlo, V, Hegedus, B, Rozsas, A, Dome, B, Marko-Varga, G
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314202/
https://ncbi.nlm.nih.gov/pubmed/25363319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12990
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