Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors

Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different antiangiogenic receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib, vatalanib) with their intratumoral distribution data...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Torok, Szilvia, Rezeli, Melinda, Kelemen, Olga, Vegvari, Akos, Watanabe, Kenichi, Sugihara, Yutaka, Tisza, Anna, Marton, Timea, Kovacs, Ildiko, Tovari, Jozsef, Laszlo, Viktoria, Helbich, Thomas H., Hegedus, Balazs, Klikovits, Thomas, Hoda, Mir Alireza, Klepetko, Walter, Paku, Sandor, Marko-Varga, Gyorgy, Dome, Balazs
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5197073/
https://ncbi.nlm.nih.gov/pubmed/28042343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.16767
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